Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019

• Autor(es): Melidou, Angeliki ; Hungnes, Olav ; Pereyaslov, Dmitriy ; Adlhoch, Cornelia ; Segaloff, Hannah ; Robesyn, Emmanuel ; Penttinen, Pasi ; Olsen, Sonja J. ; Redlberger-Fritz, Monika ; Popow-Kraupp, Therese ; Hasibra, Iris ; Simaku, Artan ; Thomas, Isabelle ; Barbezange, Cyril ; Dedeić-Ljubović, Amela ; Rodić-Vukmir, Nina ; Korsun, Neli ; Angenova, Svetla ; Draženović, Vladimir ; Koliou, Maria ; Pieridou, Despo ; Havlickova, Martina ; Nagy, Alexander ; Trebbien, Ramona ; Galiano, Monica ; Thompson, Catherine ; Ikonen, Niina ; Haveri, Anu ; Behillil, Sylvie ; Enouf, Vincent ; Valette, Martine ; Lina, Bruno ; Gavashelidze, Mari ; Machablishvili, Ann ; Gioula, Georgia ; Exindari, Maria ; Kossyvakis, Athanasios ; Mentis, Andreas ; Dürrwald, Ralf ; Zsuzsanna, Molnar ; Monika, Rozsa ; Löve, Arthur ; Erna, Gudrun ; Dunford, Linda ; Fitzpatrick, Sarah ; Castrucci, Maria Rita ; Puzelli, Simona ; Sagymbay, Altynay ; Nussupbayeva, Gaukhar ; Zamjatina, Natalija ; Pakarna, Gatis ; Griskevičius, Algirdas ; Skrickiene, Asta ; Fournier, Guillaume ; Mossong, Joel ; Melillo, Jackie ; Zahra, Graziella ; Meijer, Adam ; Fouchier, Ron ; McCaughey, Conall ; O'Doherty, Mark ; Bragstad, Karoline ; Guiomar, Raquel ; Pechirra, Pedro ; Apostol, Mariana ; Alina, Druc ; Lazar, Mihaela ; Maria, Cherciu Carmen ; Komissarov, Andrey ; Burtseva, Elena ; Gunson, Rory N. ; Shepherd, Samantha ; Tichá, Elena ; Staronova, Edita ; Prosenc, Katarina ; Berginc, Nataša ; Pozo, Francisco ; Casas, Inmaculada ; Brytting, Mia ; Wiman, Åsa ; Gonçalves, Ana Rita ; Demchyshyna, Iryna ; Mironenko, Alla ; Moore, Catherine ; Cottrell, Simon ; European Region influenza surveillance network
• Data: 2020
• Identificador Persistente: http://hdl.handle.net/10400.18/7630
• Origem: Repositório Científico do Instituto Nacional de Saúde
• Assunto(s): Antigenic; Europe; Genetic; Influenza; Surveillance; Vaccine; Infecções Respiratórias
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Científico do Instituto Nacional de Saúde

Descrição

Background: The 2018/2019 influenza season in the WHO European Region was dominated by influenza A (H1N1)pdm09 and (H3N2) viruses, with very few influenza B viruses detected. Methods: Countries in the European Region reported virus characterization data to The European Surveillance System for weeks 40/2018 to 20/2019. These virus antigenic and genetic characterization and haemagglutinin (HA) sequence data were analysed to describe and assess circulating viruses relative to the 2018/2019 vaccine virus components for the northern hemisphere. Results: Thirty countries reported 4776 viruses characterized genetically and 3311 viruses antigenically. All genetically characterized A(H1N1)pdm09 viruses fell in subclade 6B.1A, of which 90% carried the amino acid substitution S183P in the HA gene. Antigenic data indicated that circulating A(H1N1)pdm09 viruses were similar to the 2018/2019 vaccine virus. Genetic data showed that A(H3N2) viruses mostly fell in clade 3C.2a (75%) and 90% of which were subclade 3C.2a1b. A lower proportion fell in clade 3C.3a (23%) and were antigenically distinct from the vaccine virus. All B/Victoria viruses belonged to clade 1A; 30% carried a double amino acid deletion in HA and were genetically and antigenically similar to the vaccine virus component, while 55% carried a triple amino acid deletion or no deletion in HA; these were antigenically distinct from each other and from the vaccine component. All B/Yamagata viruses belonged to clade 3 and were antigenically similar to the virus component in the quadrivalent vaccine for 2018/2019. Conclusions: A simultaneous circulation of genetically and antigenically diverse A(H3N2) and B/Victoria viruses was observed and represented a challenge to vaccine strain selection.