Autor(es):
Poester, Vanice Rodrigues ; Munhoz, Lívia Silveira ; Benelli, Jéssica Louise ; Melo, Aryse Martins ; Al-Hatmi, Abdullah M.S. ; Larwood, David J. ; Martinez, Marife ; Stevens, David A. ; Xavier, Melissa Orzechowski
Data: 2022
Identificador Persistente: http://hdl.handle.net/10400.18/8551
Origem: Repositório Científico do Instituto Nacional de Saúde
Assunto(s): Candida auris; Candida Species; Antifungal Drugs; Chitin Synthase Inhibitor; Diphenyl Diselenide; in vitro Susceptibility Assays; Nikkomycin Z; Organoselenium Compounds; Infecções Sistémicas e Zoonoses
Descrição
Background: Candida auris is an emergent fungal pathogen and a global concern, mostly due to its resistance to many currently available antifungal drugs. Objective: Thus, in response to this challenge, we evaluated the in vitro activity of potential new drugs, diphenyl diselenide (PhSe)2 and nikkomycin Z (nikZ), alone and in association with currently available antifungals (azoles, echinocandins, and polyenes) against Candida auris. Methods: Clinical isolates of C. auris were tested in vitro. (PhSe)2 and nikZ activities were tested alone and in combination with amphotericin B, fluconazole, or the echinocandins, micafungin and caspofungin. Results: (PhSe)2 alone was unable to inhibit C. auris, and antagonism or indifferent effects were observed in the combination of this compound with the antifungals tested. NikZ appeared not active alone either, but frequently acted cooperatively with conventional antifungals. Conclusion: Our data show that (PhSe)2 appears to not have a good potential to be a candidate in the development of new drugs to treat C. auris, but that nikZ is worthy of further study.
