Exosomal microRNAs as possible biomarkers for a rare disease affecting lipids

• Author(s): Encarnação, Marisa ; David, Hugo ; Ribeiro, Isaura ; Vieira, Luís ; Carneiro Silva, Catarina ; Martins, Esmeralda ; Cardoso, Maria Teresa ; Futerman, Anthony H. ; Quelhas, Dulce ; Alves, Sandra
• Date: 2023
• Persistent ID: http://hdl.handle.net/10400.18/9141
• Origin: Repositório Científico do Instituto Nacional de Saúde
• Project/scholarship: info:eu-repo/grantAgreement/FCT/Concurso de Projetos de Investigação de Caráter Exploratório (PeX) em Todos os Domínios Científicos/EXPL%2FBTM-TEC%2F1477%2F2021/PT; info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00211%2F2020/PT
• Subject(s): Rare Disease; MicroRNAs; Lysosomal Storage Disorder; Genética Humana; Doenças Genéticas
• Document Type: Conference object
• Language: English
• Contributor(s): Repositório Científico do Instituto Nacional de Saúde

Description

Exosomes mediate the communication between cells and the characterization of their content can provide important insights into health and disease. Their cargo includes proteins, lipids and nucleic acids (including microRNAs (miRNAs)). miRNAs regulate many cellular processes, including metabolism. (...)

This work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project with the reference EXPL/BTM-TEC/1477/2021. We also thank the project with the reference UIDB/00211/2020