Autor(es): Mendes, M. ; Canteiro, Beatriz ; Delgadinho, Mariana ; Oliveira, Ketlyn ; Ginete, Catarina ; Gomes, Mário ; Ribeiro, Edna ; Brito, Miguel ; Gomes, Anita Q.
Data: 2022
Identificador Persistente: http://hdl.handle.net/10400.21/14931
Origem: Repositório Científico do Instituto Politécnico de Lisboa
Assunto(s): Sickle cell disease; Fetal hemoglobin; Hydroxyurea; IDI&CA-IPL/2021/EpiCa/ESTeSL; FCT_UIDB/05608/2020; FCT_UIDP/05608/2020
Purpose: Sickle cell disease (SCD) is one of the most common human genetic disorders, which is caused by a single point mutation (Glu6Val) on the HBB gene. Currently, one of the treatments for this global health problem involves the induction of fetal hemoglobin (HbF). There are some drugs on the market that pharmacologically induce HbF, namely Hydroxyurea (HU), however, their safety concerns and the expensive cost in low- and middle-income countries limit their use. In this context, it is essential to study novel fetal hemoglobin-inducing compounds that have fewer adverse effects and are widely available, such as natural compounds. Therefore, the main aim of this work was to evaluate the effects of Carica Papaya methanolic leaf extracts (CPMLE) in HbF reactivation.
