Chitosan nanoparticles loaded with minocycline targeting osteomyelitis

• Author(s): Zegre, Miguel ; Bastron, S. ; Ribeiro, I. A. ; Caetano, Liliana Aranha ; Gonçalves, L. ; Bettencourt, A.
• Date: 2022
• Persistent ID: http://hdl.handle.net/10400.21/15136
• Origin: Repositório Científico do Instituto Politécnico de Lisboa
• Subject(s): Osteomyelitis; Chitosan; Nanoparticles
• Document Type: Conference object
• Language: English
• Contributor(s): RCIPL

Description

Effective control of osteomyelitis (bone infection) with reduced toxicity is a current challenge. Targeted and controlled drug delivery systems allow: decreased toxicity, upgraded drug targeting, and improved therapeutic effect. Strategy: a) Innovative chitosan nanoparticulate system: nanoparticles loaded with minocycline (antibacterial), and alternative as a local delivery system; b) Nanoparticles and biofilms: advantages: enhanced bioavailability, targeted delivery of antibiotics magnification, local release of antibiotics, controlled and sustained release, and protection against deactivating enzymes.