Biohybrid dressings: integrating silk fibroin textiles with decellularized biological tissue for wound healing

• Author(s): Sousa, Teresa ; Vale, Inês ; Rosadas, Marta ; Silva, Inês V. ; Ribeiro, Viviana P. ; Oliveira, Ana L.
• Date: 2025
• Persistent ID: http://hdl.handle.net/10400.14/52816
• Origin: Veritati - Repositório Institucional da Universidade Católica Portuguesa
• Document Type: Report
• Language: English
• Contributor(s): Veritati

Description

Burns affect 11 million people globally each year with 180,000 associated fatalities. This study proposes a multilayer hybrid dressing combining a silk fibroin (SF) textile with decellularized porcine small intestine (dPSI) capable of simultaneously provide wound protection and tissue regeneration. A silk sericin (SS) hydrogel was embedded into the decellularized tissue ensuring the integration with the textile layer while promoting anti-inflammatory benefits, enhancing the hybrid dressing’s biological performance.