Isoenzyme characterization of Trypanosoma cruzi from congenital cases of Chagas' disease

• Author(s): Bittencourt, Achilea Candida Lisboa ; Mota, E. ; Povoa, M. ; Bittencourt, Achilea Candida Lisboa ; Mota, E. ; Povoa, M.
• Date: 2013
• Origin: Oasisbr
• Subject(s): Trypanosoma Cruzi; Doença de Chagas; Bahia
• Document Type: Journal article
• Language: English

Description

Submitted by Maria Creuza Silva ([e-mail]) on 2013-07-04T12:53:18Z No. of bitstreams: 1 Eduardo Mota. 1985. Isoenzyme Characterization of Trypanosoma Cruzy from Congenital....PDF: 5813353 bytes, checksum: 6815ae800f56afd9f07429ffd6726ec7 (MD5)

Made available in DSpace on 2013-07-04T12:53:18Z (GMT). No. of bitstreams: 1 Eduardo Mota. 1985. Isoenzyme Characterization of Trypanosoma Cruzy from Congenital....PDF: 5813353 bytes, checksum: 6815ae800f56afd9f07429ffd6726ec7 (MD5) Previous issue date: 1985

The isoenzyme profiles of a group of five Trypanosoma cruzi stocks obtained from congenital cases and of a second group of seven stocks obtained from chagasic mothers who did not transmit their infection congenitally were studied by electrophoresis of nine enzymes. All the mothers became infected in Bahia State (Brazil). With the exception of a triple 'heterozygous' GPI pattern, all T. cruzi stocks were identified as zymodeme 2 (Z2). The heterozygous pattern has not been recorded previously in Bahia. This study shows that enzymically similar T. cruzi stocks can show different behaviour with respect to transplacental transmission, and also with respect to clinicopathological presentation and therapeutic response of the congenital cases.

Liverpool