Autor(es):
Ko, Albert I. ; Reis, Joice Neves ; Coppola, Steven J. ; Gouveia, Edilane Lins ; Cordeiro, Soraia Machado ; Lôbo, Tatiana Silva ; Pinheiro, Ricardo M. ; Salgado, Kátia ; Dourado, Cibele M. Ribeiro ; Tavares-Neto, José ; Rocha, Heonir ; Reis, Mitermayer Galvão ; Johnson Jr, Warren D. ; Riley, Lee W. ; Ko, Albert I. ; Reis, Joice Neves ; Coppola, Steven J. ; Gouveia, Edilane Lins ; Cordeiro, Soraia Machado ; Lôbo, Tatiana Silva ; Pinheiro, Ricardo M. ; Salgado, Kátia ; Dourado, Cibele M. Ribeiro ; Tavares-Neto, José ; Rocha, Heonir ; Reis, Mitermayer Galvão ; Johnson Jr, Warren D. ; Riley, Lee W.
Data: 2013
Origem: Oasisbr
Assunto(s): Streptococcus pneumoniae; Meningitis
Descrição
Texto completo. Acesso restrito. p. 78-86
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Active hospital-based surveillance in the city of Salvador, Brazil, from December 1995 through October 1998, identified 221 patients with confirmed pneumococcal meningitis. Of these 221 patients, 29 (13%) had isolates with intermediate-level resistance to penicillin. Infection with these penicillin-nonsusceptible isolates was significantly associated with age of !2 years (P ! .0019), previous antibiotic use (P ! .0006), and coresistance to trimethoprimsulfamethoxazole (P ! .0000). Serotype 14 was the most prevalent serotype (55.2%) of penicillin- nonsusceptible isolates. Strain typing by repetitive element BOX polymerase chain reaction (PCR) analysis showed that penicillin-nonsusceptible serotype 14 isolates had closely related BOX PCR patterns, whereas penicillin-susceptible serotype 14 isolates each had distinct, unrelated patterns. Penicillin-nonsusceptible serotype 14 isolates from Salvador and other Brazilian cities had similar BOX PCR patterns. These observations indicate that in Brazil a large proportion of cases of penicillin-nonsusceptible pneumococcal meningitis appear to be caused by a closely related group of serotype 14 strains that may have disseminated to widely separate geographic areas.
Salvador
