Author(s):
Barros, Taís Adelita de Almeida ; Freitas, Luis A. R. de ; B. Filho, José M. ; Nunes, Xirley Pereira ; Giulietti, Ana M. ; Souza, Glória Emilia Petto de ; Santos, Ricardo R. dos ; Soares, Milena Botelho Pereira ; Villarreal, Cristiane Flora ; Barros, Taís Adelita de Almeida ; Freitas, Luis A. R. de ; B. Filho, José M. ; Nunes, Xirley Pereira ; Giulietti, Ana M. ; Souza, Glória Emilia Petto de ; Santos, Ricardo R. dos ; Soares, Milena Botelho Pereira ; Villarreal, Cristiane Flora
Date: 2013
Origin: Oasisbr
Subject(s): 7-hydroxycoumarin; Antiinflammatory; Antinociception; antipyretic; chronic pain; gastric toxicity
Description
Texto completo: acesso restrito. p. 205-213
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Objectives In the present study we investigated the antinociceptive, anti-inflammatory and antipyretic effects of 7-hydroxycoumarin (7-HC) in animal models. Methods The effects of oral 7-HC were tested against acetic acid-induced writhing, formalin test, tail flick test, complete Freund's adjuvant (CFA)-induced hypernociception, carrageenan-induced paw oedema, lipopolysaccharide-induced fever and the rota rod test. Key findings 7-HC (3–60 mg/kg) produced a dose-related antinociception against acetic acid-induced writhing in mice and in the formalin test. In contrast, treatment with 7-HC did not prevent thermal nociception in the tail flick test. A single treatment with 7-HC, 60 mg/kg, produced a long-lasting antinociceptive effect against CFA-induced hypernociception, a chronic inflammatory pain stimulus. Notably, at 60 mg/kg per day over 4 days the administration of 7-HC produced a continuous antinociceptive effect against CFA-induced hypernociception. 7-HC (30–120 mg/kg) produced anti-inflammatory and antipyretic effects against carrageenan-induced inflammation and lipopolysaccharide-induced fever, respectively. Moreover, 7-HC was found to be safe with respect to ulcer induction. In the rota rod test, 7-HC-treated mice did not show any motor performance alterations. Conclusions The prolonged antinociceptive and anti-inflammatory effects of 7-HC, in association with its low ulcerogenic activity, indicate that this molecule might be a good candidate for development of new drugs for the control of chronic inflammatory pain and fever.
