Autor(es): Sousa, Suzana Orsini Machado de ; Ferrazzo, Kivia Linhares ; Loyola, Adriano Mota ; Santos, Jean Nunes dos ; Araújo, Vera Cavalcanti de ; Sousa, Suzana Orsini Machado de ; Ferrazzo, Kivia Linhares ; Loyola, Adriano Mota ; Santos, Jean Nunes dos ; Araújo, Vera Cavalcanti de
Data: 2014
Origem: Oasisbr
Assunto(s): Kuttner tumor; Chronic sclerosing sialadenitis; Submandibular gland; Immunohistochemistry
Texto completo: acesso restrito. p. 143-149
Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-12-10T11:31:05Z No. of bitstreams: 1 10.1177-1066896907309735.pdf: 4191050 bytes, checksum: 15a266d393365c2a73fcf7018202ce83 (MD5)
Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-01-23T17:20:56Z (GMT) No. of bitstreams: 1 10.1177-1066896907309735.pdf: 4191050 bytes, checksum: 15a266d393365c2a73fcf7018202ce83 (MD5)
Made available in DSpace on 2014-01-23T17:20:56Z (GMT). No. of bitstreams: 1 10.1177-1066896907309735.pdf: 4191050 bytes, checksum: 15a266d393365c2a73fcf7018202ce83 (MD5) Previous issue date: 2008
In the present study, the immunoprofile of chronic sclerosing sialadenitis, also known as Kuttner tumor, was analyzed. Two cases that occurred in the submandibular gland of male patients were submitted to immunohistochemical reactions to different antibodies. Histological examinations showed a submandibular gland exhibiting various degrees of atrophy with destruction of acini, infiltration by inflammatory cells, and periductal fibrosis. Reactions to cytokeratins (CKs) showed acini and duct remnants positive to CKs 7, 8, 19, and 13. CK14 stained myoepithelial cells around preserved acini and intercalated duct, and also basal cell of excretory ducts, but was negative in proliferating and branching ducts. Smooth muscle actin (SMA) was expressed by myofibroblasts in periductal fibrosis, and an intense expression of extracellular components was also seen. Lymphocyte markers showed, besides mature follicles, a higher presence of CD45RO positive cells. Thus, the immunoprofile of Kuttner is much more in keeping with an inflammatory-induced degenerative disease than with a preneoplastic lesion.
