Author(s):
Cunha, Silvio do Desterro ; Macedo Junior, Fernando César de ; Costa, Giselle A. Nobre ; Rodrigues Junior, Manoel T. ; Verde, Rosival B. V. ; Souza Neta, Lourdes Cardoso de ; Vencato, Ivo ; Lariucci, Carlito ; Sá, Fernando P. ; Cunha, Silvio do Desterro ; Macedo Junior, Fernando César de ; Costa, Giselle A. Nobre ; Rodrigues Junior, Manoel T. ; Verde, Rosival B. V. ; Souza Neta, Lourdes Cardoso de ; Vencato, Ivo ; Lariucci, Carlito ; Sá, Fernando P.
Date: 2014
Origin: Oasisbr
Subject(s): Benzoylthioureas; Phenylthioureas; X-ray structure
Description
Texto completo: acesso restrito. p. 511-516
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Made available in DSpace on 2014-01-24T15:21:53Z (GMT). No. of bitstreams: 1 art%3A10.1007%2Fs00706-007-0600-y.pdf: 205436 bytes, checksum: 5a8ed5288f80c5b75e1707c1408da422 (MD5) Previous issue date: 2007
The antimicrobial activity of six N-phenyl- and fourteen N-benzoylthiourea derivatives were evaluated from their Minimal Inhibitory Concentration (MIC) values using the microdilution procedure against ten microorganisms. Most of the compounds exhibited selective activity against fungi and Gram-positive bacteria, which were very effectively inhibited by some of the tested thioureas. Additionally, SAR considerations and four novel X-ray diffraction structures of N-benzoylthioureas are included.
