Author(s): Paraná, Raymundo ; Atta, Maria Luiza Brito de Sousa ; Cabral, Milena Barreto de Arruda ; Santos, Gilvan ; Atta, Ajax Mercês ; Paraná, Raymundo ; Atta, Maria Luiza Brito de Sousa ; Cabral, Milena Barreto de Arruda ; Santos, Gilvan ; Atta, Ajax Mercês
Date: 2014
Origin: Oasisbr
Subject(s): Hepatitis C; Inflammation biomarkers; Liver histopathology; Viral genotype; Cryoglobulinemia
Texto completo: acesso restrito. p. 1101-1106
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Objective: This work investigated the profile of inflammation biomarkers in patients with chronic hepatitis C and its association with liver fibrosis, hepatic necroinflammatory activity, viral genotypes and cryoglobulinemia. Subjects and methods: Seventy-eight untreated patients were studied. Biomarker levels were determined by immunoassays, cryoglobulinemia by cryoprecipitation and liver histopathology investigated using METAVIR scores. Results: Decreased levels of α1-acid glycoprotein (AGP), C3 and haptoglobin (Hp) were observed in the patients (P < 0.0001). Increased α1-antitrypsin (P < 0.01) and ferritin (P < 0.0001) levels were found in this group, but C-reactive protein (CRP) and C4 levels were unaltered. Alanine aminotransferase inversely correlated with Hp (P < 0.01) and AGP (P = 0.01), whereas it was directly correlated with ferritin (P < 0.05) and AGP (P < 0.0001). The levels of CRP, C3 and C4 were lower in the patients with hepatic necroinflammatory activity (P < 0.05). Patients with advanced fibrosis had low levels of Hp and AGP (P < 0.05 and P < 0.01, respectively). Neither infection with different viral genotypes nor cryoglobulinemia caused an alteration in biomarker levels. Conclusion: Chronic hepatitis C virus infection alters the levels of some biomarkers, which are mainly observed in patients with liver fibrosis and hepatic necroinflammatory activity.
