Author(s): Silva, Wanderson M. ; Seyffert, Núbia ; Ciprandi, Alessandra ; Santos, Agenor V. ; Castro, Thiago Luiz de Paula ; Pacheco, Luis Gustavo Carvalho ; Barh, Debmalya ; Silva, Wanderson M. ; Seyffert, Núbia ; Ciprandi, Alessandra ; Santos, Agenor V. ; Castro, Thiago Luiz de Paula ; Pacheco, Luis Gustavo Carvalho ; Barh, Debmalya
Date: 2014
Origin: Oasisbr
Texto completo: acesso restrito. p. 460-465
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Corynebacterium pseudotuberculosis is the etiologic agent of caseous lymphadenitis a chronic infectious disease affecting small ruminants. The 2D-DIGE technique was used to compare the exoproteomes of two C. pseudotuberculosis biovar ovis strains isolated from goat (strain 1002) and sheep (strain C231). Seventeen proteins differentially produced were identified here. Nine proteins appeared over-produced in the exoproteome of 1002 goat strain and 8 in that of C231 sheep strain. These proteins were related to various biological functions, such as the cell envelope, respiratory metabolism and proteolysis. This proteomic analysis revealed strain-specific exoproteins although each of the corresponding genes was found in both strain genomes. Such differential expression pattern may reflect inter-strain differences in adaptation to a specific host, in pathogenicity and or in antigenicity of this pathogenic bacterium.
