Author(s):
Vieira, Carolina L. Z. ; Cury, Patricia Ramos ; Miname, Marcio H. ; Martinez, Lilton R. ; Bortolotto, Luiz Aparecido ; Giuliano, Isabela B. ; Santos, Raul D. ; Caramelli, Bruno ; Vieira, Carolina L. Z. ; Cury, Patricia Ramos ; Miname, Marcio H. ; Martinez, Lilton R. ; Bortolotto, Luiz Aparecido ; Giuliano, Isabela B. ; Santos, Raul D. ; Caramelli, Bruno
Date: 2014
Origin: Oasisbr
Subject(s): Carotid artery diseases; Hypercholesterolemia; Inflammation; Periodontal disease; Risk factors
Description
p. 683-688
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Made available in DSpace on 2014-10-07T14:48:14Z (GMT). No. of bitstreams: 1 Patricia R. Cury.pdf: 515168 bytes, checksum: 88fef89bc44f574506e133c1bf50fa6b (MD5) Previous issue date: 2011
Background: This pilot study evaluates the association of severe periodontitis with pulse wave velocity (PWV), carotid artery intima-medial thickness (IMT), and clinical, metabolic, and atherogenic inflammatory markers in 79 subjects with heterozygous familial hypercholesterolemia (hFH). All subjects were free of previous vascular disease manifestations. Methods: The body mass index (in kilograms per square meter), plasma lipids, glucose, C-reactive protein, and white blood cell counts were evaluated. After full-mouth periodontal examinations, patients were categorized into the severe periodontitis group (SPG) or non-severe periodontitis group (NSPG). Results: The SPG showed significantly higher values of cholesterol-year scores, triglycerides, glucose, PWV, IMT, and diastolic blood pressure (DBP) (P ≤0.05) than the NSPG. After adjustment for traditional risk factors for atherosclerosis, only the association between severe periodontitis and DBP (odds ratio: 3.1; 95% CI: 1.1 to 8.5; P = 0.03) was confirmed. Conclusion: In individuals with hFH, severe periodontitis was associated with a higher DBP, which suggests that severe periodontitis, itself, may contribute to the increased cardiovascular risk profile in this population.
