Autor(es):
Mello, Leonardo Araújo ; Figueiredo, Andréia Leal ; Ramos, Eduardo Antônio Gonçalves ; Gurgel, Clarissa Araujo Silva ; Martins, Manoela Domingues ; Figueiredo, Claúdia Roberta Leite Vieira de ; Cury, Patricia Ramos ; Albuquerque Júnior, Ricardo Luiz Cavalcanti de ; Ramalho, Luciana Maria Pedreira ; Santos, Jean Nunes dos ; Mello, Leonardo Araújo ; Figueiredo, Andréia Leal ; Ramos, Eduardo Antônio Gonçalves ; Gurgel, Clarissa Araujo Silva ; Martins, Manoela Domingues ; Figueiredo, Claúdia Roberta Leite Vieira de ; Cury, Patricia Ramos ; Albuquerque Júnior, Ricardo Luiz Cavalcanti de ; Ramalho, Luciana Maria Pedreira ; Santos, Jean Nunes dos
Data: 2014
Origem: Oasisbr
Assunto(s): Dendritic cell; E-cadherin; Langerhans cell; Odontogenic tumors
Descrição
Texto completo: acesso restrito. p. 454–461
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Background: Ameloblastomas and keratocystic odontogenic tumors (KOTs) are lesions that are characterized by locally invasive growth and cause extensive bone destruction. In addition, it is known that E-cadherin influences the adhesion of Langerhans cells (LCs) to keratinocytes. Objective and Methods: The aim of this study was to investigate, using immunohistochemistry, the distribution of CD1a-positive cells in ameloblastomas and KOTs and their relationship with E-cadherin, in comparison to calcifying cystic odontogenic tumor (CCOT). Results: The CD1a-positive LCs were observed in 11 ameloblastomas and KOTs. All of the cases of CCOT showed CD1a-positive LCs and a significant difference was found when this tumor was compared with ameloblastomas (P < 0.05, Mann–Whitney test). A statistically significant difference was also noted when comparing CD1a-positive LCs between CCOTs and KOTs (P < 0.05, Mann–Whitney test). Lower expression of E-cadherin in ameloblastomas (AMs) in relation to KOTs and CCOTs (P < 0.05, Fisher test) was observed. There was no correlation between E-cadherin and CD1a-positive LCs between all odontogenic tumors that were studied (P > 0.05, Spearman test). Conclusion: A quantitative difference of CD1a-positive cells between AMs and KOTs in comparison to CCOTs was observed. This permits to speculate that a depletion of CD1a-positive LCs might influence the local invasiveness of ameloblastomas and KOTs. Furthermore, it is suggested that E-cadherin mediates cell adhesion in these tumors.
