Author(s):
Araujo, Natália Motta de ; Araujo, Oscar Rafael Carmo ; Silva, Edinete Melo da ; Villella-Nogueira, Cristiane Alves ; Nabuco, Letícia Cancella ; Paraná, Raymundo ; Bessone, Fernando ; Gomes, Selma de Andrade ; Trepo, Christian ; Kay, Alan Campbell ; Araujo, Natália Motta de ; Araujo, Oscar Rafael Carmo ; Silva, Edinete Melo da ; Villella-Nogueira, Cristiane Alves ; Nabuco, Letícia Cancella ; Paraná, Raymundo ; Bessone, Fernando ; Gomes, Selma de Andrade ; Trepo, Christian ; Kay, Alan Campbell
Date: 2015
Origin: Oasisbr
Subject(s): Hepatitis B; Hepatitis B virus; HBeAg; AIDS Serodiagnosis
Description
Texto completo: acesso restrito. p.150-158
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Hepatitis B virus (HBV) genotype G (HBV/G) infection is almost always detected along with a co-infecting HBV strain that can supply HBeAg, typically HBV/A2. In this study we describe, in two human immunodeficiency virus (HIV)-positive patients from Argentina and Brazil, the first report of HBV/G infection in Argentina and co-circulation of HBV/G, HBV/F and G/F recombinants in the American continent. HBV isolates carrying the 36 bp insertion of HBV/G were the most prevalent in both patients, with >99 % of colonies hybridizing to a probe specific for this insertion. Phylogenetic analyses of full-length genomes and precore/core fragments revealed that F4 and F1b were the co-infecting subgenotypes in the Brazilian and Argentinian patients, respectively. Bootscanning analysis provided evidence of recombination in several clones from both patients, with recombination breakpoints located mainly at the precore/core region. These data should encourage further investigations on the clinical implications of HBV/G recombinants in HBV/HIV co-infected patients.
