Author(s):
Mueller, Noel T. ; Duncan, Bruce Bartholow ; Barreto, Sandhi Maria ; Chor, Dóra ; Bessel, Marina ; Aquino, Estela Maria Motta Lima Leão de ; Pereira, Mark A ; Schmitd, Maria Inês ; Mueller, Noel T. ; Duncan, Bruce Bartholow ; Barreto, Sandhi Maria ; Chor, Dóra ; Bessel, Marina ; Aquino, Estela Maria Motta Lima Leão de ; Pereira, Mark A ; Schmitd, Maria Inês
Date: 2015
Origin: Oasisbr
Subject(s): Puberty; Menarche; Diabetes; Cardiometabolic Risk; Metabolic Syndrome; Obesity; Nutrition Transition; Primordial Prevention; Epidemiology
Description
Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2015-06-09T12:49:16Z No. of bitstreams: 1 Estela Aquino 2014.pdf: 186700 bytes, checksum: 65dd604ed7c20963361354ae481141fb (MD5)
Made available in DSpace on 2015-06-09T12:49:16Z (GMT). No. of bitstreams: 1 Estela Aquino 2014.pdf: 186700 bytes, checksum: 65dd604ed7c20963361354ae481141fb (MD5) Previous issue date: 2014
Objectives: Early menarche has been linked to higher risk of type 2 diabetes in Western and Asian societies, yet whether age at menarche is associated with diabetes in Latin America, where puberty and diabetes may have different life courses, is unknown. We tested the hypothesis that earlier menarche is associated with higher diabetes risk in Brazilian adults. Methods: We used data from 8,075 women aged 35-74 years in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) who had complete information on age at menarche, diabetes status, and covariates. Diabetes was defined based on self-reported physician diagnosis, medication use, and laboratory variables (fasting glucose, 2-hour glucose, and glycated hemoglobin). Poisson regression was used to generate risk ratios (RR) and 95% confidence intervals (CI). Results: Menarche onset < 11 years [vs. 13-14 years referent)] was associated with higher risk of diabetes (RR = 1.34; 95% CI: 1.14-1.57) after adjusting for sociodemographic factors, maternal education, maternal and paternal diabetes, and birth weight. This persisted after further control for BMI at age 20 years and relative leg length. Additionally, among those not taking diabetes medications, earlier menarche [<11 years vs. 13-14 years (referent)] was associated with higher % glycated hemoglobin (p < 0.001), alanine aminotransferase (p < 0.001), triglycerides (p < 0.001), C-reactive protein (p = 0.003), waist circumference (p < 0.001), and BMI measured at baseline exam (p < 0.001). Conclusion: These findings support the hypothesis that earlier menarche is associated with greater risk for adult diabetes and cardiometabolic disease in the Brazilian context.
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