Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review

• Author(s): Strina, Agostino ; Barreto, Mauricio Lima ; Cooper, Philip J. ; Rodrigues, Laura C. ; Strina, Agostino ; Barreto, Mauricio Lima ; Cooper, Philip J. ; Rodrigues, Laura C.
• Date: 2015
• Origin: Oasisbr
• Subject(s): Mould; Non-Atopic Asthma; Non-Atopic Wheeze; Respiratory Infections; Risk Factors
• Document Type: Journal article
• Language: English

Description

Submitted by Maria Creuza Silva ([e-mail]) on 2015-06-09T13:45:01Z No. of bitstreams: 1 Strina A. 2014.pdf: 465732 bytes, checksum: 3b5011498b91f1e43a44bfe7561126ac (MD5)

Made available in DSpace on 2015-06-09T13:45:01Z (GMT). No. of bitstreams: 1 Strina A. 2014.pdf: 465732 bytes, checksum: 3b5011498b91f1e43a44bfe7561126ac (MD5) Previous issue date: 2014

Background: The study of non-atopic asthma/wheeze in children separately from atopic asthma is relatively recent. Studies have focused on single risk factors and had inconsistent findings. Objective: To review evidence on factors associated with non-atopic asthma/wheeze in children and adolescents. Methods: A review of studies of risk factors for non-atopic asthma/wheeze which had a non-asthmatic comparison group, and assessed atopy by skin-prick test or allergen-specific IgE. Results: Studies of non-atopic asthma/wheeze used a wide diversity of definitions of asthma/wheeze, comparison groups and methods to assess atopy. Among 30 risk factors evaluated in the 43 studies only 3 (family history of asthma/rhinitis/eczema, dampness/mold in the household, and lower respiratory tract infections in childhood)showed consistent associations with non-atopic asthma/wheeze. No or limited period of breastfeeding was less consistently associated with non-atopic asthma/wheeze. The few studies examining the effects of overweight/obesity and psychological/social factors showed consistent associations. We used a novel graphical presentation of different risk factors for non-atopic asthma/wheeze, allowing a more complete perception of the complex pattern of effects. Conclusions: More research using standardized methodology is needed on the causes of non-atopic asthma.

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