Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study.

• Author(s): Cardoso, Cristiane Wanderley ; Ribeiro, Guilherme Sousa ; Reis, Mitermayer Galvão ; Flannery, Brendan ; Reis, Joice Neves
• Date: 2016
• Origin: Oasisbr
• Subject(s): Meningococcal Disease; Meningococcal Vaccine; Epidemic
• Document Type: Journal article
• Language: English

Description

Submitted by Maria Creuza Silva ([e-mail]) on 2016-05-03T17:30:47Z No. of bitstreams: 1 Art Per Estrang Guilherme Ribeiro3. 2015.pdf: 192847 bytes, checksum: 3923e714bd34177a85d9eee7b9e02bb0 (MD5)

Made available in DSpace on 2016-05-03T17:30:47Z (GMT). No. of bitstreams: 1 Art Per Estrang Guilherme Ribeiro3. 2015.pdf: 192847 bytes, checksum: 3923e714bd34177a85d9eee7b9e02bb0 (MD5) Previous issue date: 2015-04

During a citywide epidemic of serogroup C meningococcal disease in Salvador in 2010, Brazil, the state government initiated mass vaccination targeting two age groups with high attack rates: individuals aged <5 years and 10–24 years. More than 600,000 doses of meningococcal serogroup C conjugate vaccines were administered. We performed a casecontrol study to evaluate vaccine uptake, document vaccine effectiveness and identify reasons for non-vaccination. Methods and Findings Population-based surveillance identified patients with laboratory-confirmed invasive meningococcal C (MenC) disease during 2010. Information on MenC vaccination was obtained from case patients and age-matched individuals from the same neighborhoods. MenC vaccine effectiveness was estimated based on the exact odds ratios obtained by conditional logistic regression analysis. Of 51 laboratory-confirmed cases of serogroup C meningococcal disease among patients <5 and 10–24 years of age 50 were included in the study and matched with 240 controls. Overall case-fatality was 25%.MenC vaccine coverage among controls increased from 7.1%to 70.2% after initiation of the vaccination campaign. None of the 50 case patients but 70 (29.2%) of the 240 control individuals, including 59 (70.2%) of 84 matched with cases from the period afterMenC vaccination, had received at least one MenC vaccine dose. Overall effectiveness of MenC was 98%with a lower 95%exact confidence limit of 89%. Conclusions MenC vaccines administered during the meningococcal epidemic were highly effective, suggesting that rapid vaccine uptake through campaigns contributed to control of meningococcal disease.

San Francisco