Author(s): Queiroz, Ciro Oliveira ; Pitanga, Francisco ; Lotufo, Paulo Andrade ; Molina, Maria Del Carmen Bisi ; Aquino, Estela Maria Motta Lima Leão de ; Almeida, Maria Conceição Chagas
Date: 2021
Origin: Oasisbr
Subject(s): Motor Activity; Risk Factors; ROC Curve; Cardiovascular Diseases; Inflammation
Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2021-11-04T18:39:23Z No. of bitstreams: 1 Amount of physical activity necessary for a normal level.pdf: 258138 bytes, checksum: 8f4c99a9743e21fb0e1c77ecfd36efc9 (MD5)
Approved for entry into archive by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2021-11-04T19:11:15Z (GMT) No. of bitstreams: 1 Amount of physical activity necessary for a normal level.pdf: 258138 bytes, checksum: 8f4c99a9743e21fb0e1c77ecfd36efc9 (MD5)
Made available in DSpace on 2021-11-04T19:11:15Z (GMT). No. of bitstreams: 1 Amount of physical activity necessary for a normal level.pdf: 258138 bytes, checksum: 8f4c99a9743e21fb0e1c77ecfd36efc9 (MD5) Previous issue date: 2020-02
BACKGROUND:Studies have shown that physical activity levels can be inversely associated with high-sensitivity C-reactive protein (hs-CRP) levels. However, the amount of physical activity required to maintain normal hs-CRP levels is still a matter for speculation. OBJECTIVE: To identify the amount of physical activity necessary to discriminate the hs-CRP levels in adults. DESIGN AND SETTING: Cross-sectional study at six teaching and research institutions.METHODS: The study sample comprised 10,231 adults aged 35 to 74 years who were participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Receiver operating characteristic (ROC) curves were constructed to compare the amount of physical activity in two domains (leisure time and commuting) with hs-CRP levels. The sensitivity and specificity were calculated to identify the best cutoff for physical activity level that would be needed to maintain normal levels of hs-CRP (< 3 mg/l).c. RESULTS: The area under the ROC curve was only statistically significant for discriminating normal levels of hs-CRP according to the amount of physical activity when the two study domains were added together. The accumulated physical activity level of 200 minutes/week was the best cutoff for discriminating normal levels of hs-CRP in adults of both sex. CONCLUSIONS: Physical activity in the leisure-time and commuting domains together, of duration 200 minutes /week, was associated with normal hs-CRP values.
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