Author(s): Arguelho, Maria Lara Palmeira de Macedo ; Alves, José do Patrocínio Hora ; Stradiotto, Nelson Ramos ; Lacerda Júnior, Valdemar ; Pires, José Maria ; Beatriz, Adilson
Date: 2011
Origin: Oasisbr
Subject(s): Amodiaquina; Guanina; Adutos do DNA; Amodiaquine; Guanine; DNA Adducts
The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA. The anodic peak is dependent on pH, scan rate and the concentration of the pharmaceutical. Adduct formation is irreversible in nature, and preferentially occurs by interaction of the amodiaquine with the guanine group. Theoretical calculations for optimization of geometry, and DFT analyses and on the electrostatic potential map (EPM), were used in the investigation of adduct formation between amodiaquine and DNA.
