Autor(es):
OHASHI, Camila Melo ; CALDEIRA, Fabio Alves Morikawa ; FEITOSA JUNIOR, Denilson José Silva ; VALENTE, André Lopes ; DUTRA, Paulo Roberto Witter ; MIRANDA, Moysés dos Santos ; SANTOS, Simone do Socorro Damasceno ; BRITO, Marcus Vinicius Henriques ; OHASHI, Otávio Mitio ; YASOJIMA, Edson Yuzur ; https://orcid.org/0000-0001-7771-8174 ; https://orcid.org/0000-0003-1476-0054 ; https://orcid.org/0000-0002-1377-4895
Data: 2017
Origem: Oasisbr
Assunto(s): Células-tronco; Tecido adiposo; Cicatrização; Histologia; Adipose tissue; Wound healing; Stem cells; Rats
Descrição
PURPOSE: To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats. METHODS: Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylineosin was performed. RESULTS: All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions. CONCLUSION: Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.
