Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid beta-peptide-induced apoptosis

• Autor(es): Sola, Susana ; Amaral, Joana D. ; Borralho, Pedro M. ; Ramalho, Rita M. ; Castro, Rui E. ; Aranha, Marcia M. ; Steer, Cifford J. ; Rodrigues, Cecilia M. P.
• Data: 2006
• Identificador Persistente: http://hdl.handle.net/10451/21085
• Origem: Repositório da Universidade de Lisboa
• Assunto(s): Endocrinology & Metabolism
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Científico de Acesso Aberto da ULisboa

Descrição

Tauroursodeoxycholic acid ( TUDCA) prevents amyloid beta-peptide (A beta)-induced neuronal apoptosis, by modulating both classical mitochondrial pathways and specific upstream targets. In addition, activation of nuclear steroid receptors (NSRs), such as t