Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits viral replication

• Author(s): Goncalves, J ; Silva, F ; Freitas-Vieira, A ; Santa-Marta, M ; Malho, R ; Yang, X ; Gabuzda, D ; Barbas, C
• Date: 2002
• Persistent ID: http://hdl.handle.net/10451/21598
• Origin: Repositório da Universidade de Lisboa
• Subject(s): Immunology; Infectious Diseases; Virology
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório Científico de Acesso Aberto da ULisboa

Description

Human immunodeficiency virus type 1 (HIV-1) encoded Vif protein is important for viral replication and infectivity. Therefore, Vif is considered to be an important alternative therapeutic target for inhibition of viral infectivity at the level of viral as