Intrabodies targeting the Kaposi sarcoma-associated herpesvirus latency antigen inhibit viral persistence in lymphoma cells

• Author(s): Corte-Real, S ; Collins, C ; da Silva, FA ; Simas, JP ; Barbas, CF ; Chang, Y ; Moore, P ; Goncalves, J
• Date: 2005
• Persistent ID: http://hdl.handle.net/10451/21605
• Origin: Repositório da Universidade de Lisboa
• Subject(s): Hematology
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório Científico de Acesso Aberto da ULisboa

Description

Kaposi sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen-1 (LANA1) is essential for the maintenance and segregation of viral episomes in KSHV latently infected B cells. We report development of intracellular, rabbit-derived antibodi