The rigid amphipathic fusion Inhibitor dUY11 acts through photosensitization of viruses

• Autor(es): Vigant, Frederic ; Hollmann, Axel ; Lee, Jihye ; Santos, Nuno C. ; Jung, Michael E. ; Lee, Benhur
• Data: 2014
• Identificador Persistente: http://hdl.handle.net/10451/23601
• Origem: Repositório da Universidade de Lisboa
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Científico de Acesso Aberto da ULisboa

Descrição

Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inverted-cone-shaped molecules thought to antagonize the membrane curvature transitions that occur during virus-cell fusion and are broad-spectrum antivirals against enveloped viruses (Broad-SAVE). Here, we show that RAFIs act like membrane-binding photosensitizers: their antiviral effect is dependent on light and the generation of singlet oxygen (1O2), similar to the mechanistic paradigm established for LJ001, a chemically unrelated class of Broad-SAVE. Photosensitization of viral membranes is a common mechanism that underlies these Broad-SAVE.