Dairy intake and Parkinson's disease: a Mendelian randomization study

• Author(s): Domenighetti, Cloé ; Sugier, Pierre‐Emmanuel ; Ashok Kumar Sreelatha, Ashwin ; Schulte, Claudia ; Grover, Sandeep ; Mohamed, Océane ; Portugal, Berta ; May, Patrick ; Bobbili, Dheeraj R. ; Radivojkov‐Blagojevic, Milena ; Lichtner, Peter ; Singleton, Andrew B. ; Hernandez, Dena G. ; Edsall, Connor ; Mellick, George D. ; Zimprich, Alexander ; Pirker, Walter ; Rogaeva, Ekaterina ; Lang, Anthony E. ; Koks, Sulev ; Taba, Pille ; Lesage, Suzanne ; Brice, Alexis ; Corvol, Jean‐Christophe ; Chartier‐Harlin, Marie‐Christine ; Mutez, Eugénie ; Brockmann, Kathrin ; Deutschländer, Angela B. ; Hadjigeorgiou, Georges M. ; Dardiotis, Efthimos ; Stefanis, Leonidas ; Simitsi, Athina Maria ; Valente, Enza Maria ; Petrucci, Simona ; Duga, Stefano ; Straniero, Letizia ; Zecchinelli, Anna ; Pezzoli, Gianni ; Brighina, Laura ; Ferrarese, Carlo ; Annesi, Grazia ; Quattrone, Andrea ; Gagliardi, Monica ; Matsuo, Hirotaka ; Kawamura, Yusuke ; Hattori, Nobutaka ; Nishioka, Kenya ; Chung, Sun Ju ; Kim, Yun Joong ; Kolber, Pierre ; Warrenburg, Bart P.C. ; Bloem, Bastiaan R. ; Aasly, Jan ; Toft, Mathias ; Pihlstrøm, Lasse ; Correia Guedes, Leonor ; Ferreira, Joaquim J ; Bardien, Soraya ; Carr, Jonathan ; Tolosa, Eduardo ; Ezquerra, Mario ; Pastor, Pau ; Diez‐Fairen, Monica ; Wirdefeldt, Karin ; Pedersen, Nancy L. ; Ran, Caroline ; Belin, Andrea C. ; Puschmann, Andreas ; Hellberg, Clara ; Clarke, Carl E. ; Morrison, Karen E. ; Tan, Manuela ; Krainc, Dimitri ; Burbulla, Lena F. ; Farrer, Matt J. ; Krüger, Rejko ; Gasser, Thomas ; Sharma, Manu ; Elbaz, Alexis
• Date: 2022
• Persistent ID: http://hdl.handle.net/10451/51089
• Origin: Repositório da Universidade de Lisboa
• Subject(s): Dairy intake; Parkinson's disease; Mendelian randomization
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório Científico de Acesso Aberto da ULisboa

Description

Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029). Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.