Adipose tissue-associated cancer risk: is it the fat around the liver, or the fat inside the liver?

• Autor(es): Marchesini, Giulio ; Petroni, Maria Letizia ; Cortez-Pinto, Helena
• Data: 2019
• Identificador Persistente: http://hdl.handle.net/10451/56432
• Origem: Repositório da Universidade de Lisboa
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Científico de Acesso Aberto da ULisboa

Descrição

The association between obesity and cancer risk has been extensively characterized. In a prospective study of more than 900,000 adults free of cancer at enrollment and observed during a 16-year follow-up, Calle et al. were able to calculate the risk of mortality for cancer at different sites in relation to body mass index (BMI), as well as the proportion of all deaths from cancer attributable to overweight and obesity. In both men and women, a high BMI increased the risk of cancer, and for several cancers the risk appeared to increase in a BMI-dependent manner. The authors concluded that overweight and obesity in the adult US population could account for 14% of all cancer deaths in men and 20% of those in women. Notably, cancer at liver site was recorded as one of the sites at higher risk, particularly in men. These data were confirmed by analysis of cancer incidence rates in 221 databases, including nearly 300,000 cases of cancer at different sites, with obesity accounting for a variable population attributable fraction of all cancers.