Author(s): Meira, Jorge ; Marques, Maria Luís ; Falcão-Reis, Fernando ; Gomes, Eva ; Carneiro, Ângela
Date: 2020
Persistent ID: http://hdl.handle.net/10400.16/2564
Origin: Repositório Científico da Unidade Local de Saúde de Santo António (ULSSA)
Subject(s): adverse reactions; fluorescein; hypersensitivity reaction; indocyanine green; ophthalmic dyes; retinal angiography
Introduction: Contrast rapid sequence angiography with fluorescein or indocyanine green (ICG) is a diagnostic procedure commonly used in ophthalmology. Adverse reactions to fluorescein and ICG are rare and may be classified as toxic, of hypersensitivity and non-specific. The evaluation and management of a patient with an adverse reaction is a challenge for the majority of ophthalmologists, as is the assessment of risk factors that may contraindicate the procedure. Purpose: We aim to review the concepts underlying adverse reactions to fluorescein and ICG, especially those of hypersensitivity, and present a proposal or the evaluation of the patients in need to perform retinal angiography and for the treatment of immediate reactions to fluorescein and ICG. Methods: The available literature was examined using PubMed-Medline, and using the MeSH terms "fluorescein", "Indocyanine green", "ophthalmic dyes", "retinal angiography", "adverse reactions", and "allergic reaction". Conclusion: This review may help ophthalmologists to identify patients with higher risk of a hypersensitivity reaction and give them tools to recognize patients with suspected hypersensitivity that may benefit from an allergy study.
