Author(s): Rodrigues, Mosar Corrêa ; Morais, José Athayde Vasconcelos ; Ganassin, Rayane ; Oliveira, Giulia Rosa Tavares ; Costa, Fabiana Chagas ; Morais, Amanda Alencar Cabral ; Silveira, Ariane Pandolfo ; Silva, Victor Carlos Mello ; Longo, João Paulo Figueiró ; Muehlmann, Luis Alexandre
Date: 2022
Origin: Oasisbr
Subject(s): Morte celular imunogênica; Câncer - tratamento; Sistema imunológico
Immunogenic cell death (ICD) is a modality of regulated cell death that is sufficient to promote an adaptive immune response against antigens of the dying cell in an immunocompetent host. An important characteristic of ICD is the release and exposure of damage-associated molecular patterns, which are potent endogenous immune adjuvants. As the induction of ICD can be achieved with conventional cytotoxic agents, it represents a potential approach for the immunotherapy of cancer. Here, different aspects of ICD in cancer biology and treatment are reviewed.
