Autor(es): Teixeira Carvalho, Marcia Dias ; Alonso, Diego Peres [UNESP] ; Vieira Vendrame, Celia Maria ; Costa, Dorcas Lamounier ; Nery Costa, Carlos Henrique ; Werneck, Guilherme Loureiro ; Martins Ribolla, Paulo Eduardo [UNESP] ; Goto, Hiro
Data: 2015
Identificador Persistente: http://hdl.handle.net/11449/117230
Origem: Oasisbr
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Laboratorio de Investigacao Medica
In visceral leishmaniasis (VL) endemic areas, a minority of infected individuals progress to disease since most of them develop protective immunity. Therefore, we investigated the risk markers of VL within nonimmune sector. Analyzing infected symptomatic and, asymptomatic, and noninfected individuals, VL patients presented with reduced high-density lipoprotein cholesterol (HDL-C), elevated triacylglycerol (TAG), and elevated very-low-density lipoprotein cholesterol (VLDL-C) levels. A polymorphism analysis of the lipoprotein lipase (LPL) gene using HindIII restriction digestion (N = 156 samples) (H+ = the presence and H = the absence of mutation) revealed an increased adjusted odds ratio (OR) of VL versus noninfected individuals when the H+/H+ was compared with the H-/H-genotype (OR = 21.3; 95% CI = 2.32-3335.3; P = 0.003). The H+/H+ genotype and the H+ allele were associated with elevated VLDL-C and TAG levels (P < 0.05) and reduced HDL-C levels (P < 0.05). An analysis of the L162V polymorphism in the peroxisome proliferator-activated receptor alpha (PPAR alpha) gene (n = 248) revealed an increased adjusted OR when the Leu/Val was compared with the Leu/Leu genotype (OR = 8.77; 95% CI = 1.41-78.70; P = 0.014). High TAG (P = 0.021) and VLDL-C (P = 0.023) levels were associated with susceptibility to VL, whereas low HDL (P = 0.006) levels with resistance to infection. The mutated LPL and the PPAR alpha Leu/Val genotypes may be considered risk markers for the development of VL.
Univ Sao Paulo, Inst Med Trop Sao Paulo, Lab Soroepidemiol & Imunobiol, BR-05403000 Sao Paulo, Brazil
Univ Estadual Paulista, Inst Biociencias, Dept Parasitol, BR-18618970 Botucatu, SP, Brazil
Univ Fed Piaui, Inst Doencas Trop Natan Portella, BR-64001450 Teresina, PI, Brazil
Univ Estado Rio de Janeiro, Inst Social Med, Dept Epidemiol, BR-20550900 Rio De Janeiro, RJ, Brazil
Univ Fed Rio de Janeiro, Inst Estudos Saude Colet, BR-21941598 Rio De Janeiro, RJ, Brazil
Univ Sao Paulo, Fac Med, Dept Prevent Med, BR-01246903 Rio De Janeiro, RJ, Brazil
Univ Estadual Paulista, Inst Biociencias, Dept Parasitol, BR-18618970 Botucatu, SP, Brazil
CNPq: 154581/2006-2
FAPESP: 06/60006-9
Laboratorio de Investigacao MedicaLIM/38 HC-FMUSP
