Author(s): Morandim, Andréia de Araújo ; Cotinguiba, Fernando [UNESP] ; Regasini, Luis Octavio [UNESP] ; Frigieri, Mariana Carina [UNESP] ; Varanda, Eliana Aparecida [UNESP] ; Coqueiro, Aline [UNESP] ; Kato, Massuo Jorge ; Bolzani, Vanderlan da Silva [UNESP] ; Furlan, Maysa [UNESP]
Date: 2015
Persistent ID: http://hdl.handle.net/11449/122438
Origin: Oasisbr
Subject(s): Piperaceae; Piper tuberculatum; (Z)-piplartine; mutagenic activated; Ames test.
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Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.
Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química e Ciências Ambientais, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054000, SP, Brasil
Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química e Ciências Ambientais, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054000, SP, Brasil
1Departamento de Química Orgânica, Instituto de Química, Universidade Estadual de São Paulo, Rua Francisco Degni, s/n, 14800-900 Araraquara-SP, Brazil.
Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Rodovia Araraquara/Jaú Km 1, 14801-902 Araraquara-SP, Brazil.
FAPESP
CNPq
