Author(s): Melo, Nathalie Ferreira Silva de [UNESP] ; Grillo, Renato [UNESP] ; Fraceto, Leonardo Fernandes [UNESP] ; Dias Filho, Newton Luiz [UNESP] ; Paula, Eneida de ; Araújo, Daniele Ribeiro de ; Rosa, André Henrique [UNESP]
Date: 2015
Persistent ID: http://hdl.handle.net/11449/123422
Origin: Oasisbr
Subject(s): nanocapsulas; benzocaína; caracterização físico-química
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In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of –38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.
Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Engenharia Ambiental, Sorocaba, Av. Três de Março, 511, Alto da Boa Vista, CEP 18087180, SP, Brasil
Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Engenharia Ambiental, Sorocaba, Av. Três de Março, 511, Alto da Boa Vista, CEP 18087180, SP, Brasil
