Autor(es): Peresi, Eliana [UNESP] ; Oliveira, Larissa Ragozo Cardoso [UNESP] ; Silva, Weber Laurentino da ; Costa, Erika Alessandra Pellison Nunes da [UNESP] ; Araujo, João Pessoa [UNESP] ; Ayres, Jairo Aparecido [UNESP] ; Fortes, Maria Rita Parise [UNESP] ; Graviss, Edward A. ; Pereira, Ana Carla [UNESP] ; Calvi, Sueli Aparecida [UNESP]
Data: 2015
Identificador Persistente: http://hdl.handle.net/11449/130938
Origem: Oasisbr
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Cytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN- γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF -308 A allele with higher TNF- α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 -819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF- β plasma levels in PTB patients at T2. The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 -819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.
Universidade Estadual Paulista, Departamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu
Universidade Estadual Paulista, Departamento de Microbiologia e Imunologia, Instituto de Biociências de Botucatu
Universidade Estadual Paulista, Departamento de Enfermagem, Faculdade de Medicina de Botucatu
Universidade Estadual Paulista, Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de Botucatu
