Author(s): Santos, Juliana Alves dos ; Corrales, Roberta Cristina Novaes Reis ; Pavan, Fernando Rogério [UNESP] ; Leite, Clarice Queico Fujimura [UNESP] ; Dias, Rafael Mafra de Paula ; Silva, Adilson David da
Date: 2016
Persistent ID: http://hdl.handle.net/11449/133718
Origin: Oasisbr
Subject(s): Carbohydrate; Glycoconjugates; 1,2,3-triazole; Antitubercular activity
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Coordenação de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms.
Universidade Federal de Juiz de Fora, Departamento de Química, Instituto de Ciências Exatas
Universidade Estadual Paulista, Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas de Araraquara
FAPESP: 2008/10390-2
FAPESP: 2009/06499-1
