Author(s): Paganotte, Daniele Michelin [UNESP] ; Sannomiya, Miriam ; Rinaldo, Daniel [UNESP] ; Vilegas, Wagner [UNESP] ; Salgado, Herida R. N. [UNESP]
Date: 2018
Persistent ID: http://hdl.handle.net/11449/161943
Origin: Oasisbr
Subject(s): Batata-depurga; HPLC-UV-PDA; Laxative; Operculina Macrocarapa; Phenolic acids
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Operculina macrocarpa (L.) Urb., Convolvulaceae, is used by the population as a laxative. In this work we described the isolation of the three phenolic acids present in the hydroethanolic extract of the O. macrocarpa roots. The quantification of the caffeic, chlorogenic acids and of the new caffeic dimer in the hydroethanolic and infusion extracts was performed by high-performance liquid chromatography coupled photodiode array detector. These analyses showed the higher content of the chlorogenic, caffeic and the new 3,4'-dehydrodicaffeic acid in hydroethanolic and hydroethanolic extracts without resin in which infusion. The acid found in greater quantity is caffeic acid followed by the 3,4'-dehydrodicaffeic acid. The laxative activity was evaluated by different experimental models of intestinal transit with the hydroethanolic and infusion extracts, and the resin fraction, caffeic, chlorogenic and ferulic acids. The results showed all extracts and compounds tested had significant activity in the experimental model tested. These results obtained are essential for the future development of a pharmaceutical product with safety and efficacy. (C) 2016 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda.
Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Med, Programa Posgrad Ciencias Farmaceut, Araraquara, SP, Brazil
Univ Sao Paulo, Escola Artes Ciencias & Humanidades, Sao Paulo, SP, Brazil
Univ Estadual Paulista, Fac Ciencias, Dept Quim, Bauru, SP, Brazil
Univ Estadual Paulista, Campus Litorai Paulista, Sao Vicente, SP, Brazil
Ctr Univ Herminio Ometto, Fundacao Heiminio Ometto, Araras, SP, Brazil
Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Farmacos & Med, Programa Posgrad Ciencias Farmaceut, Araraquara, SP, Brazil
Univ Estadual Paulista, Fac Ciencias, Dept Quim, Bauru, SP, Brazil
Univ Estadual Paulista, Campus Litorai Paulista, Sao Vicente, SP, Brazil
