Author(s): Melo Ribeiro, Mariana Goveia ; Marcolino, Larissa Doddi [UNESP] ; Andrade Ramos, Bruna Ribeiro de [UNESP] ; Miranda, Elaine Alves ; Trento, Cleverson Luciano [UNESP] ; Jain, Sona ; Gurgel, Ricardo Queiroz ; Silva, Marcia Guimaraes da [UNESP] ; Dolabella, Silvio Santana
Date: 2018
Persistent ID: http://hdl.handle.net/11449/162479
Origin: Oasisbr
Subject(s): Papilomaviridae; Mouth mucosa; Epidemiology; Brazil
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FAPITEC/SE - Fundacao de Apoio a Pesquisa e Inovacao Tecnilogica do Estado do Sergipe
The role of human papillomavirus (HPV) in oral carcinogenesis is still controversial as detection rates of the virus in oral cavity reported in the literature varies greatly. Objective: The aim of this study was to evaluate the frequency of HPV infection and its genotypes in patients with oral lesions at the Ambulatory of Oral Diagnosis of the Federal University of Sergipe, Brazil. Material and Methods: We conducted a molecular study with 21 patients (15 females) aged from two to 83 years with clinically detectable oral lesions. Samples were collected through exfoliation of lesions and HPV-DNA was identified using MY09/11 and GP5+/6+ primers. Genotyping was performed by multiplex PCR. Results: Benign, premalignant and malignant lesions were diagnosed by histopathology. HPV was detected in 17 samples. Of these, HPV-6 was detected in 10 samples, HPV-18 in four and HPV-16 in one sample. When samples were categorized by lesion types, HPV was detected in two papilloma cases (2/3), five carcinomas (5/6), one hyperplasia (1/1) and nine dysplasia cases (9/11). Conclusion: Unlike other studies in the literature, we reported high occurrence of HPV in oral lesions. Further studies are required to enhance the comprehension of natural history of oral lesions.
Univ Fed Sergipe, Dept Morfol, Lab Entomol & Parasitol Trop, Sao Cristovao, SE, Brazil
Univ Estadual Paulista, Fac Med Botucatu, Dept Patol, Botucatu, SE, Brazil
Univ Fed Sergipe, Dept Odontol, Aracaju, SE, Brazil
Univ Fed Sergipe, Dept Med, Aracaju, SE, Brazil
Univ Estadual Paulista, Fac Med Botucatu, Dept Patol, Botucatu, SE, Brazil
FAPITEC/SE - Fundacao de Apoio a Pesquisa e Inovacao Tecnilogica do Estado do Sergipe: MS/CNPq/ FAPITEC/SE/SES 02/2013 - PPSUS Sergipe
