Author(s): Marques, Ana Paula C. ; Oliveira, Sandra Maria V. L. ; Rezende, Grazielli R. ; Melo, Dayane A. ; Fernandes-Fitts, Sonia M. ; Pontes, Elenir Rose J. C. ; Bonecini-Almeida, Maria da Gloria ; Camargo, Zoilo P. ; Mendes, Rinaldo P. [UNESP] ; Paniago, Anamaria M. M.
Date: 2018
Persistent ID: http://hdl.handle.net/11449/163215
Origin: Oasisbr
Subject(s): Paracoccidioidic infection; Booster phenomenon; Intradermal tests; Paracoccidioides brasiliensis; Paracoccidioidomycosis; gp43
Made available in DSpace on 2018-11-26T17:40:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-01
Health Department of the Municipality of Jaraguari (Mato Grosso do Sul, Brazil)
Post-Graduation Program for Health and Development of the Central-West Region Brazil
We estimated the occurrence rate of the booster phenomenon by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis in the central-west region of Brazil. Individuals who had a negative result on a survey performed by using an intradermal test with 43 kDa glycoprotein in an endemic area of paracoccidioidomycosis underwent a second intradermal test after 10-15 days to determine the presence or absence of the booster phenomenon. Statistical analyses were performed using the Chi-square test, Chi-square for linear trend test, Student's t test, and binomial test; p < 0.05 was considered significant. For the first time, we reported the occurrence of the booster phenomenon to an intradermal reaction caused by 43 kDa glycoprotein at a rate of 5.8-8.4%, depending on the test's cutoff point. This suggests that a cutoff point should be considered for the booster phenomenon in intradermal tests with 43 kDa glycoprotein: a difference of 6-7 mm between readings according to the first and second tests, depending on the purpose of the evaluation. The results indicate that the prevalence of paracoccidioidal infection in endemic areas is underestimated, as the booster phenomenon has not been considered in epidemiological surveys for this infection.
Univ Fed Mato Grosso do Sul, Fac Med, Cidade Univ S-N, BR-79070900 Campo Grande, Brazil
Fundacao Oswaldo Cruz, Evandro Chagas Clin Res Inst, Lab Immunol & Immunogenet, BR-21040360 Rio De Janeiro, Brazil
Univ Fed Sao Paulo, Fac Med, Clin Hosp, Med Mycol Lab, BR-04023062 Sao Paulo, Brazil
Univ Estadual Paulista, Fac Med Botucatu, Dept Trop Dis, Botucatu, SP, Brazil
Univ Estadual Paulista, Fac Med Botucatu, Dept Trop Dis, Botucatu, SP, Brazil
