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Made available in DSpace on 2018-11-26T17:55:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-03-18
Health Ministry of Brazil (Ministerio da Saude do Brasil)
Objective: To analyze unfavorable outcomes at hospital discharge of preterm infants born at Brazilian public university centers.Methods: Prospective cohort of 2646 inborn infants with gestational age 23-33 weeks and birth weight 400-1499g, without malformations, born at 20 centers in 2012-2013. Unfavorable outcome was defined as in-hospital death or survival at hospital discharge with 1 major morbidities: bronchopulmonary dysplasia (BPD) at 36 corrected weeks, intraventricular hemorrhage (IVH) grades 3-4, periventricular leukomalacia (PVL) or surgically treated retinopathy of prematurity (ROP).Results: Among 2646 infants, 1390 (53%) either died or survived with major morbidities: 793 (30%) died; 497 (19%) had BPD; 358 (13%) had IVH 3-4 or PVL; and 84 (3%) had ROP. Logistic regression adjusted by center showed association of unfavorable outcome with: antenatal steroids (OR 0.70; 95%CI 0.55-0.88), C-section (0.72; 0.58-0.90), gestational age <30 (4.00; 3.16-5.07), being male (1.44; 1.19-1.75), small for gestational age (2.19; 1.72-2.78), 5th-min Apgar <7 (3.89; 2.88-5.26), temperature at NICU admission <36.0 degrees C (1.42; 1.15-1.76), respiratory distress syndrome (3.87; 2.99-5.01), proven late sepsis (1.33; 1.05-1.69), necrotizing enterocolitis (3.10; 2.09-4.60) and patent ductus arteriosus (1.69; 1.37-2.09).Conclusions: More than half of the VLBW infants born at public university level 3 Brazilian hospitals either die or survive with major morbidities.
Univ Fed Sao Paulo, Escola Paulista Med, BR-01410 Sao Paulo, SP, Brazil
Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
Univ Estadual Campinas, Ctr Atencao Integral Saude Mulher, Hosp Mulher Prof Jose Aristodemo Pinotti, Campinas, SP, Brazil
Pontificia Univ Catolica Rio Grande do Sul, Dept Pediat, Porto Alegre, RS, Brazil
Univ Fed Maranhao, Univ Hosp, Sao Luis, MA, Brazil
Univ Fed Uberlandia, Fac Med, Hosp Clin, BR-38400 Uberlandia, MG, Brazil
Univ Sao Paulo, Fac Med, Hosp Clin, Sao Paulo, SP, Brazil
Fac Ciencias Med Minas Gerais, Belo Horizonte, MG, Brazil
Fundacao Oswaldo Cruz, Inst Fernandes Figueira, Rio De Janeiro, RJ, Brazil
Hosp Geral Pirajussara, Sao Paulo, SP, Brazil
Univ Estadual Londrina, Univ Hosp, Londrina, PR, Brazil
Univ Estadual Paulista, Fac Med Botucatu, Botucatu, SP, Brazil
Univ Fed Parana, Dept Pediat, BR-80060000 Curitiba, Parana, Brazil
Univ Sao Paulo, Fac Med Ribeirao Preto, Sao Paulo, SP, Brazil
Inst Med Integral Prof Fernando Figueira, Recife, PE, Brazil
Univ Sao Paulo, Fac Med, Univ Hosp, Sao Paulo, SP, Brazil
Hosp Estadual Sumare, Sumare, SP, Brazil
Hosp Estadual Diadema, Sao Paulo, SP, Brazil
Univ Estado Rio de Janeiro, BR-20550011 Rio De Janeiro, RJ, Brazil
Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil
Univ Estadual Paulista, Fac Med Botucatu, Botucatu, SP, Brazil
Health Ministry of Brazil (Ministerio da Saude do Brasil): MS/VIGISUS 1755/2000
Health Ministry of Brazil (Ministerio da Saude do Brasil): MS/FNS 274
Health Ministry of Brazil (Ministerio da Saude do Brasil): FIOCRUZ/PDTSP
