Author(s):
Espindola Lima, Glaucia Moreira ; Nunes, Maina de Oliveira ; Chang, Marilene Rodrigues ; Sousa Tsujisaki, Rosianne Assis de ; Nunes, Joslaine de Oliveira ; Taira, Cleison Ledesma ; Thomaz, Danilo Yamamoto ; Barbaro Del Negro, Gilda Maria ; Mendes, Rinaldo Poncio [UNESP] ; Miranda Paniago, Anamaria Mello
Date: 2018
Persistent ID: http://hdl.handle.net/11449/165931
Origin: Oasisbr
Subject(s): Urine infections; Antifungal agents; Nosocomial candiduria; Candida species; Antifungal susceptibility
Description
Made available in DSpace on 2018-11-29T05:07:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01. Added 1 bitstream(s) on 2019-10-09T18:25:54Z : No. of bitstreams: 1 S0036-46652017005000245.pdf: 306084 bytes, checksum: 57207ba4a5bdbb2942a11c602ab1beb6 (MD5)
FUNDECT
The aim of this study was to identify Candida spp. isolated from candiduria episodes at a tertiary hospital in the Midwest region of Brazil, and to determine their susceptibility profiles to antifungal compounds. From May 2011 to April 2012, Candida spp. isolated from 106 adult patients with candiduria admitted to the University Hospital of the Federal University of Mato Grosso do Sul were evaluated. Both, species identification and susceptibility testing with fluconazole-FLC, voriconazole-VRC, and amphotericin B-AmB were carried out using the Vitek 2. To discriminate species of the C. parapsilosis complex, a RAPD-PCR technique using the RPO2 primer was performed. From the total of 106 isolates, 42 (39.6%) C. albicans and 64 (60.4%) Candida non-albicans (CNA) -33 C. tropicalis, 18 C. glabrata, 5 C. krusei, 4 C. parapsilosis sensu stricto, 2 C. kefyr, 1 C. lusitaniae, and 1 C. guilliermondii were identified. All isolates were susceptible to AmB and VRC, whereas all C. glabrata isolates presented either resistance (5.6%) or dose-dependent susceptibility (94.4%) to FLC. The study of Candida spp. and their resistance profiles may help in tailoring more efficient therapeutic strategies for candiduria.
Univ Fed Mato Grosso do Sul, Hosp Univ Maria Aparecida Pedrossian, Lab Anal Clin, Campo Grande, MS, Brazil
Univ Fed Mato Grosso do Sul, Fac Ciencias Farmaceut Alimentos & Nutr, Campo Grande, MS USA
Univ Sao Paulo, Inst Med Trop Sao Paulo, Lab Micol Med LIM 53, Sao Paulo, SP, Brazil
Univ Estadual Paulista, Fac Med, Botucatu, SP, Brazil
Univ Fed Mato Grosso do Sul, Fac Med, Ave Senador Fillinto,Muller,355, BR-79070900 Campo Grande, MS, Brazil
Univ Estadual Paulista, Fac Med, Botucatu, SP, Brazil
