Description
Made available in DSpace on 2018-11-29T18:48:45Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-04-01
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Medical Research Council of the United Kingdom
Parvoviruses (family Parvoviridae) are small, single-stranded DNA viruses. Many parvoviral pathogens of medical, veterinary and ecological importance have been identified. In this study, we used high-throughput sequencing (HTS) to investigate the diversity of parvoviruses infecting wild and domestic animals in Brazil. We identified 21 parvovirus sequences (including twelve nearly complete genomes and nine partial genomes) in samples derived from rodents, bats, opossums, birds and cattle in Pernambuco, Sdo Paulo, Paran6 and Rio Grande do Sul states. These sequences were investigated using phylogenetic and distance-based approaches and were thereby classified into eight parvovirus species (six of which have not been described previously), representing six distinct genera in the subfamily Parvovirinae. Our findings extend the known biogeographic range of previously characterized parvovirus species and the known host range of three parvovirus genera (Dependovirus, Aveparvovirus and Tetraparvovirus). Moreover, our investigation provides a window into the ecological dynamics of parvovirus infections in vertebrates, revealing that many parvovirus genera contain well-defined sub-lineages that circulate widely throughout the world within particular taxonomic groups of hosts.
Univ Sao Paulo, Ribeirao Preto Med Sch, Virol Res Ctr, BR-14049900 Ribeirao Preto, SP, Brazil
MRC Univ Glasgow, Ctr Virus Res, Glasgow G61 1QH, Lanark, Scotland
Univ Sao Paulo, Inst Biomed Sci, BR-05508900 Sao Paulo, SP, Brazil
Univ Fed Fronteira Sul, BR-99010200 Passo Fundo, RS, Brazil
Univ Estadual Centro Oeste, BR-85015430 Guarapuava, Parana, Brazil
Sao Paulo State Univ, Fac Vet Med, BR-16050680 Aracatuba, SP, Brazil
Minist Hlth, Ctr Technol Innovat, Evandro Chagas Inst, BR-67030000 Ananindeua, Para, Brazil
Sao Paulo State Univ, Fac Vet Med, BR-16050680 Aracatuba, SP, Brazil
FAPESP: 13/14929-1
FAPESP: 17/13981-0
FAPESP: 12/24150-9
FAPESP: 15/05778-5
FAPESP: 16/01414-1
FAPESP: 14/20851-8
FAPESP: 06/00572-0
FAPESP: 08/06411-4
FAPESP: 11/06810-9
FAPESP: 11/22663-6
FAPESP: 16/02568-2
FAPESP: 09/05994-9
FAPESP: 11/13821-7
Medical Research Council of the United Kingdom: MC_UU_12014/10
