Description
Made available in DSpace on 2018-12-11T16:48:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-06-01
Fundação Oswaldo Cruz
The influence of hepatitis B virus (HBV) genotypes in the natural history of the disease and its response to antiviral treatment have been addressed in many studies. In Brazil, studies on HBV genotype circulation have been restricted to specific population groups and states. Here, we have conducted a nationwide multicentre study with an unprecedented sample size representing all Brazilian regions in an effort to better understand the viral variants of HBV circulating among chronic carriers. Seven HBV genotypes were found circulating in Brazil. Overall, HBV/A was the most prevalent, identified in 589 (58.7 %) samples, followed by HBV/D (23.4 %) and HBV/F (11.3 %). Genotypes E, G, C and B were found in a minor proportion. The distribution of the genotypes differed markedly from the north to the south of the country. While HBV/A was the most prevalent in the North (71.6 %) and Northeast (65.0 %) regions, HBV/D was found in 78.9 % of the specimens analysed in the South region. HBV/F was the second most prevalent genotype in the Northeast region (23.5 %). It was detected in low proportions (7 to 10 %) in the North, Central-West and Southeast regions, and in only one sample in the South region. HBV/E was detected in all regions except in the South, while monoinfection with HBV/G was found countrywide, with the exception of Central-West states. Our sampling covered 24 of the 26 Brazilian states and the Federal District and is the first report of genotype distribution in seven states. This nationwide study provides the most complete overview of HBV genotype distribution in Brazil to date and reflects the origin and plurality of the Brazilian population.
Laboratório de Hepatites Virais Instituto Oswaldo Cruz FIOCRUZ
Fundação de Medicina Tropical Doutor Heitor Vieira Dourado
Laboratório de Imunologia Clínica Departamento de Análise Clínicas e Biomedicina Universidade Estadual de Maringá
Laboratório do Grupo de Estudo das Hepatites UNICAMP
Laboratório de Hepatites Instituto Adolfo Lutz
Laboratório Central de Saúde Pública Noel Nutels
Laboratório Central de Saúde Pública do Estado da Bahia
Universidade Estadual Paulista (Unesp) Faculdade de Ciências Agronômicas (FCA), Campus de Botucatu
Universidade Estadual Paulista (Unesp) Faculdade de Medicina (FMB) Divisão Hemocentro Laboratório de Biologia Molecular, Campus de Botucatu
Laboratório de Biologia Molecular do Hemocentro Faculdade de Medicina de Botucatu UNESP
Laboratório Central de Saúde Pública do Ceará
Laboratório Central de Saúde Pública da Bahia
Laboratório Central de Saúde Pública do Mato Grosso do Sul
Universidade de Brasília
Departamento de DST AIDS e Hepatites Virais
Universidade Estadual de Maringá
Instituto Adolfo Lutz
Universidade Estadual Paulista (Unesp) Faculdade de Ciências Agronômicas (FCA), Campus de Botucatu
Universidade Estadual Paulista (Unesp) Faculdade de Medicina (FMB) Divisão Hemocentro Laboratório de Biologia Molecular, Campus de Botucatu
Laboratório de Biologia Molecular do Hemocentro Faculdade de Medicina de Botucatu UNESP
Fundação Oswaldo Cruz: 495.687
