Autor(es): Moço, Natália Prearo [UNESP] ; Martin, Laura Fernandes [UNESP] ; De Andrade Ramos, Bruna Ribeiro [UNESP] ; De Camargo, Rodrigo Paupério Soares ; Sarmento, Stephanno Gomes Pereira ; Fernandes, Karayna Gil ; Filho, Dionísio Chiaratto ; Miot, Hélio Amante [UNESP] ; Da Silva, Márcia Guimarães [UNESP]
Data: 2018
Identificador Persistente: http://hdl.handle.net/11449/173062
Origem: Oasisbr
Assunto(s): Inflammatory response; Innate immunity; Soluble receptors
Made available in DSpace on 2018-12-11T17:03:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01
Background: Triggering receptors expressed on myeloid cells-1 (TREM-1) are innate immune receptors that mediate inflammatory response. In recent times, the role of these receptors has become the focus of several studies in the gestational context. Evaluation of soluble TREM-1 concentration in normal pregnancy is scarce, and no data are available on the levels of this receptor in the last weeks of normal pregnancy. Method: Amniotic fluid (AF) samples were obtained from 77 patients in the last weeks of normal pregnancy during cesarean section, and the soluble form of TREM-1 (sTREM-1) levels determined using specific sandwich enzyme-linked immunosorbent assay kit. Results: sTREM-1 was detectable in all AF samples, and its levels did not vary in the last weeks of third trimester pregnancy. There was no correlation between sTREM-1 levels in AF and advancing gestational age. Conclusion: sTREM-1 is a physiologic constituent of AF and its levels are not temporally regulated in pregnancies at term.
Department of Pathology Botucatu Medical School São Paulo State University UNESP
Department of Dermatology Botucatu Medical School São Paulo State University UNESP
Department of Obstetrics and Gynecology Jundiaí Medical School
Bom Jesus Hospital
Department of Pathology Botucatu Medical School São Paulo State University UNESP
Department of Dermatology Botucatu Medical School São Paulo State University UNESP
