Description
Made available in DSpace on 2018-12-11T17:14:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01
Made available in DSpace on 2018-12-11T17:14:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01
Made available in DSpace on 2018-12-11T17:14:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01
Made available in DSpace on 2018-12-11T17:14:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01
Made available in DSpace on 2018-12-11T17:14:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01
The wound healing is a complex process which, sometimes, can be a problem in public health because of the possibility of physical disability or even death. Due to the lack of a gold standard drug in skin wound treatment and aiming at the discovery of new treatments in skin repair and the mechanisms involved in the process, we used oleoresin (OR) from Copaifera langsdorffii and hydroalcoholic extract of the leaves (EH) to treat rat skin wounds. For that, male Wistar rats were divided into groups (n=8): Lanette, Collagenase, 10% EH, or 10% OR and, after anesthesia, one wound of 2 cm was made in the back of animals. The wounds were treated once a day for 3, 7, or 14 days and the wound areas were measured. The rats were euthanized and skin samples destined to biochemical, molecular, and immunohistochemical analysis. The results showed a macroscopic retraction of the wounds of 10% EH and 10% OR creams and both treatments showed anti-inflammatory activity. Molecular and immunohistochemical results demonstrated the activity of Copaifera langsdorffii creams in angiogenesis, reepithelialization, wound retraction, and remodeling mechanisms.
Department of Morphology Institute of Biosciences of Botucatu UNESP
Department of Surgery and Veterinary Anesthesiology School of Veterinary Medicine and Animal Science UNESP
Department of Pharmaceutical Sciences School of Pharmaceutical Sciences of Ribeiraõ Preto University of Saõ Paulo Campus Ribeiraõ Preto
Department of Biostatistics Institute of Biosciences of Botucatu UNESP
Department of Morphology Institute of Biosciences of Botucatu UNESP
Department of Surgery and Veterinary Anesthesiology School of Veterinary Medicine and Animal Science UNESP
Department of Biostatistics Institute of Biosciences of Botucatu UNESP
