Autor(es): Amaral, Thaeny C. ; Miguel, Fábio B. ; Couri, Mara R.C. ; Corbi, Pedro P. ; Carvalho, Marcos A. ; Campos, Débora L. [UNESP] ; Pavan, Fernando R. [UNESP] ; Cuin, Alexandre
Data: 2018
Identificador Persistente: http://hdl.handle.net/11449/176019
Origem: Oasisbr
Assunto(s): Cinnamaldehyde; Metal ions; Powder diffraction; Schiff bases; Tuberculosis
Made available in DSpace on 2018-12-11T17:18:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-05-15
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Silver(I) and zinc(II) complexes with N,N′-bis(trans-cinnamaldehyde)ethane-1,2-diamine (EnCinn) have been synthesized and characterized by elemental analysis, simultaneous thermogravimetric and differential thermal studies (TG-DTA), infrared (IR), 1H and 13C nuclear magnetic resonance (NMR) spectroscopic measurements and electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-QTOF-MS). Crystal and molecular structure descriptions were performed based on powder X-ray diffraction data. The AgEnCinn complex has a polymeric structure where the ligand bridges between two Ag(I) ions, while the ZnEnCinn complex has a monomeric structure with EnCinn acting as chelating ligand. Antimycobacterial assays over Mycobacterium tuberculosis showed the activity of the Ag(I) complex with Minimum Inhibitory Concentration (MIC) value of 22.7 μmol L−1, while the Zn(II) complex was shown to be inactive over the same experimental conditions.
LQBin Laboratório de Química BioInorgânica Departamento de Química Instituto de Ciências Exatas UFJF
Departamento de Química Instituto de Ciências Exatas UFJF
Instituto de Química Universidade Estadual de Campinas UNICAMP, 13083-970, Campinas
Laboratório de Pesquisas em Tuberculose Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas UNESP
Laboratório de Pesquisas em Tuberculose Departamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas UNESP
