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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Ketoprofen is an analgesic with potent anti-inflammatory activity against acute inflammation, subacute inflammation, for the acute and long-term treatment of various inflammatory pathologies, as rheumatoid arthritis and colonic adenocarcinoma. In order to minimize the incidence of systemic events related to ketoprofen, the transdermal drug delivery system development has been most important. The advantages of using natural rubber latex membranes include not only the reduction of adverse systemic events, but also the suitability of the low cost of the material together with its physicochemical properties such as flexibility, mechanical stability, surface porosity and water vapor permeability, and besides being a biocompatible material also presents biological activity to stimulate the angiogenesis, being able to be used in tissue repair. This study demonstrated that ketoprofen was successfully incorporated into natural latex membranes for drug delivery. FTIR indicated that the drug did not interact chemically with the membrane. Moreover, the natural latex membranes released 60% of the ketoprofen incorporated in 50 h. SEM images indicated that a portion of the drug was present on the membrane surface, being this portion responsible for the burst release. The tensile tests showed that the addition of the drug into the natural latex membrane did not influence on the polymer mechanical behavior. In addition, drug-natural latex membranes presented no red blood cell damaging effects. Our data shows that the ketoprofen loaded natural latex membranes is a promising system for sustained drug delivery which can be used to minimize the adverse side effects of high dose systemic drug delivery.
School of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube Avenue
Institute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni Street
School of Pharmaceutical Sciences São Paulo State University (UNESP), Km 01, Araraquara-Jaú Road
School of Sciences Humanities and Languages São Paulo State University (UNESP), 2100 Dom Antônio Avenue
Faculty of Medicine São Paulo University (USP), 3900 Bandeirantes Avenue
UFTM – ICBN, 330 Manoel Mendes Square, Biochemistry Section
Department of physics School of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube Avenue
Pharmaceutical Science Center Institute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni Street
School of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube Avenue
Institute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni Street
School of Pharmaceutical Sciences São Paulo State University (UNESP), Km 01, Araraquara-Jaú Road
School of Sciences Humanities and Languages São Paulo State University (UNESP), 2100 Dom Antônio Avenue
Department of physics School of Sciences São Paulo State University (UNESP), 14-01 Eng. Luiz Edmundo Carrijo Coube Avenue
Pharmaceutical Science Center Institute of Chemistry São Paulo State University (UNESP), 55 Prof. Francisco Degni Street
FAPESP: 2014/17526-8
CAPES: 470261/2012-9
