Autor(es): Vieira, Gabriela Alves Licursi [UNESP] ; Silva, Marco Túlio Alves da ; Regasini, Luis Octávio [UNESP] ; Cotinguiba, Fernando [UNESP] ; Laure, Helen Julie ; Rosa, José César ; Furlan, Maysa [UNESP] ; Cicarelli, Regina Maria Barretto [UNESP]
Data: 2018
Identificador Persistente: http://hdl.handle.net/11449/180031
Origem: Oasisbr
Assunto(s): Piplartine; Proteome; Therapeutic targets; Trypanosomatids
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The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas’ disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effective during the chronic phase. Therefore, it is extremely urgent to find innovative chemotherapeutic agents and/or effective vaccines. Since piplartine has several biological activities, including trypanocidal activity, the present study aimed to evaluate it on two T. cruzi strains proteome. Considerable changes in the expression of some important enzymes involved in parasite protection against oxidative stress, such as tryparedoxin peroxidase (TXNPx) and methionine sulfoxide reductase (MSR) was observed in both strains. These findings suggest that blocking the expression of the two enzymes could be potential targets for therapeutic studies.
Universidade Estadual Paulista – UNESP Instituto de Química
Universidade Estadual Paulista – UNESP Instituto de Biociências Letras e Ciências Exatas
Universidade Estadual Paulista – UNESP Faculdade de Ciências Farmacêuticas
Universidade de São Paulo Faculdade de Medicina de Ribeirão Preto Centro de Química de Proteínas
Universidade de São Paulo Instituto de Física de São Carlos
Instituto de Pesquisas de Produtos Naturais (IPPN) Centro de Ciências da Saúde Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Estadual Paulista – UNESP Instituto de Química
Universidade Estadual Paulista – UNESP Instituto de Biociências Letras e Ciências Exatas
Universidade Estadual Paulista – UNESP Faculdade de Ciências Farmacêuticas
