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Made available in DSpace on 2014-05-20T13:50:50Z (GMT). No. of bitstreams: 2 WOS000306687700090.pdf: 141400 bytes, checksum: 41b50410cc0558fe568f834ce2b9577a (MD5) WOS000306687700090.pdf.txt: 37081 bytes, checksum: bdfe065e7a523b5cf4259fe56d5437d8 (MD5) Previous issue date: 2012-07-23
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Faculdade de Medicina de Botucatu - UNESP
Introduction: Micronutrient deficiency is observed in heart failure patients. Taurine, for example, represents 50% of total free amino acids in the heart, and in vivo studies have linked taurine deficiency with cardiomyopathy.Methods: Thirty-four male Wistar rats (body weight = 100 g) were weighed and randomly assigned to one of two groups: Control (C) or taurine-deficient (T (-)). Beta-alanine at a concentration of 3% was added to the animals' water to induce taurine deficiency in the T (-) group. on day 30, the rats were individually submitted to echocardiography; morphometrical and histopathological evaluation and metalloproteinase activity, oxidative stress and inflammation evaluation were performed. Tissue samples were collected to determine the taurine concentration in the heart.Results: Taurine deficiency led to decreases in: ventricular wall thickness, left ventricle dry weight, myocyte sectional area, left ventricle posterior wall thickness and ventricular geometry. With regard to heart function, the velocity of the A wave, the ratio between the E and A wave, the ejection fraction, fractional shortening and cardiac output values were decreased in T () rats, suggesting abnormal diastolic and systolic function. Increased fibrosis, inflammation and increased activation of metalloproteinases were not observed. Oxidative stress was increased in deficient animals.Conclusions: These data suggest that taurine deficiency promotes structural and functional cardiac alterations with unique characteristics.
Univ Estadual Paulista UNESP, Fac Med Botucatu, Dept Internal Med, Botucatu, SP, Brazil
Univ Estadual Paulista UNESP, Inst Biociencias Botucatu, Dept Microbiol & Immunol, Botucatu, SP, Brazil
Univ Estadual Paulista UNESP, Inst Biociencias Botucatu, Dept Chem & Biochem, Botucatu, SP, Brazil
Univ São Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Internal Med, Ribeirao Preto, SP, Brazil
Univ Estadual Paulista UNESP, Fac Med Botucatu, Dept Internal Med, Botucatu, SP, Brazil
Univ Estadual Paulista UNESP, Inst Biociencias Botucatu, Dept Microbiol & Immunol, Botucatu, SP, Brazil
Univ Estadual Paulista UNESP, Inst Biociencias Botucatu, Dept Chem & Biochem, Botucatu, SP, Brazil
