Description
Made available in DSpace on 2019-10-04T12:14:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-01
This prospective cohort study aimed to assess the association of admission hypothermia (AH) with death and/or major neonatal morbidities among very low birth weight (VLBW) preterm infants based on the relative performance of 20 centers of the Brazilian Network of Neonatal Research. This is a retrospective analysis of prospectively collected data using the database registry of the Brazilian Network on Neonatal Research. Center performance was defined by the relative mortality rate using conditional inference trees. A total of 4356 inborn singleton VLBW preterm infants born between January 2013 and December 2016 without malformations were included in this study. The centers were divided into two groups: G1 (with lower mortality rate) and G2 (with higher mortality rate). Crude and adjusted relative risks (RR) and 95% confidence intervals (95%CI) were estimated by simple and multiple log-binomial regression models. An AH rate of 53.7% (19.8-93.3%) was significantly associated with early neonatal death in G1 (adjusted RR 1.41, 95% CI 1.09-1.84) and G2 (adjusted RR 1.29, 95%CI 1.01-1.65) and with in-hospital death in G1 (adjusted RR 1.29, 95%CI 1.07-1.58). AH was significantly associated with a lower frequency of necrotizing enterocolitis (adjusted RR 0.58, 95%CI 38-0.88) in G2.Conclusion: AH significantly associated with early neonatal death regardless of the hospital performance. In G2, an unexpected protective association between AH and necrotizing enterocolitis was found, whereas the other morbidities assessed were not significantly associated with AH.
Univ Estadual Campinas, Fac Ciencias Med, Dept Pediat, Campinas, SP, Brazil
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pediat, Ave Bandeirantes 3900, BR-14049900 Sao Paulo, Brazil
Univ Fed Sao Paulo, Div Neonatal Med, Sao Paulo, Brazil
Univ Sao Paulo, Dept Pediat, Sch Med, Sao Paulo, Brazil
Inst Crianca, Ave Dr Eneas de Carvalho Aguiar,647 Pinheiros, BR-05403000 Sao Paulo, Brazil
Univ Fed Rio Grande do Sul, HCPA, Div Neonatol, Rua Silva Jardim 1155-701, BR-90450071 Porto Alegre, RS, Brazil
Maternidade Hilda Brandao, Fac Ciencias Med Minas Gerais, Dept Pediat, Belo Horizonte, MG, Brazil
Hosp Geral Pirajussara, Neonatal Unit, Taboao Da Serra, Brazil
Univ Estadual Paulista, Fac Med Botucatu, Div Neonatol, Botucatu, SP, Brazil
Univ Fed Uberlandia, Dept Pediat, Uberlandia, MG, Brazil
Univ Fed Maranhao, Dept Pediat, Sao Luis, Brazil
Pontificia Univ Catolica Rio Grande do Sul, Fac Med, Hosp Sao Lucas, Dept Pediat, Porto Alegre, RS, Brazil
Univ Estado Rio de Janeiro, Hosp Univ Pedro Ernesto, Dept Pediat, Rio De Janeiro, Brazil
Inst Med Integral Prof Fernando Figueira, Dept Pediat, Recife, PE, Brazil
Fundacao Oswaldo Cruz, Div Neonatol, Rio De Janeiro, Brazil
Univ Estadual Londrina, Dept Pediat, Univ Hosp, Curitiba, Parana, Brazil
Hosp Estadual Diadema, Neonatal Unit, Diadema, Brazil
Univ Fed Parana, Hosp Clin, Dept Pediat, Curitiba, Parana, Brazil
Univ Fed Minas Gerais, Div Neonatol, Belo Horizonte, MG, Brazil
Hosp Estadual Sumare, Neonatal Div, Sumare, Brazil
Univ Estadual Paulista, Fac Med Botucatu, Div Neonatol, Botucatu, SP, Brazil
