Autor(es): Sylvestre, Tatiane Fernanda [UNESP] ; Cavalcante, Ricardo de Souza [UNESP] ; Silva, Julhiany de Fátima da [UNESP] ; Paniago, Anamaria Mello Miranda ; Weber, Simone Schneider ; Pauletti, Bianca Alves ; Carvalho, Lídia Raquel de [UNESP] ; Santos, Lucilene Delazari dos [UNESP] ; Mendes, Rinaldo Poncio [UNESP]
Data: 2019
Identificador Persistente: http://hdl.handle.net/11449/188266
Origem: Oasisbr
Made available in DSpace on 2019-10-06T16:02:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-10-01
National Physical Laboratory
Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Despite the effective treatment, quiescent fungi can lead to relapse, usually late, the serological diagnosis of which has been deficient. The present study was carried out with the objective of investigating a biomarker for the identification of PCM relapse and another molecule behaving as an immunological recovery biomarker; therefore, it may be used as a cure criterion. In the evolutionary analysis of the proteins identified in PCM patients, comparing those that presented with those that did not reveal relapse, 29 proteins were identified. The interactions observed between the proteins, using transferrin and haptoglobin, as the main binding protein, were strong with all the others. Patient follow-up suggests that cerulosplamin may be a marker of relapse and that transferrin and apolipoprotein A-II may contribute to the evaluation of the treatment efficacy and avoiding a premature decision.
Universidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu
Universidade Federal de Mato Grosso do Sul (UFMS) Faculdade de Medicina
Instituto de Ciências Exatas e Tecnologia (ICET) Universidade Federal do Amazonas (UFAM)
Laboratório Nacional de Biociências–CNPEM
Universidade Estadual Paulista (UNESP) Instituto de Biociência de Botucatu
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP) UNESP
Universidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu
Universidade Estadual Paulista (UNESP) Instituto de Biociência de Botucatu
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP) UNESP
National Physical Laboratory: 13083–970
